Prothrombotic State and Cardiovascular Risk in Hyperuricaemic Individuals: Does Hyperglycaemia Play a Role? A Case-control Study
Published: September 1, 2020 | DOI: https://doi.org/10.7860/JCDR/2020/44949.14041
Shilpa Bhardwaj, Ashok Ahirwar, Bhawesh Mishra, Gaurav Singla, Anju Jain
1. Assistant Professor, Department of Biochemistry, Rajiv Gandhi Super Speciality Hospital, Delhi, India.
2. Assistant Professor, Department of Biochemistry, AIIMS, Nagpur, Maharashtra, India.
3. Specialist, Department of Biochemistry, Deen Dayal Upadhyay Hospital, Delhi, India.
4. Assistant Professor, Department of Cardiology, Rajiv Gandhi Super Speciality Hospital, Delhi, India.
5. Director-Professor, Department of Biochemistry, Lady Harding Medical College and Associated Hospital, Delhi, India.
Correspondence
Dr. Shilpa Bhardwaj,
186, Ground Floor, Sharda Niketan, Pitampura, Delhi-34, India.
E-mail: drshilpa2001@gmail.com
Introduction: The role of Hyperuricaemia (HU) in pathogenesis of cardiovascular disorders is debated. A number of hypothetical mechanisms that link HU to increased cardiovascular risk are researched.
Aim: To evaluate the hypercoagulable state and cardiovascular risk in diabetic hyperuricaemics, nondiabetic hyperuricaemics in comparison to healthy controls, and to analyse whether chronic hyperglycaemia has a causal role in HU associated cardiovascular risk.
Materials and Methods: A case-control study was conducted in which 60 known hyperuricaemic cases and 30 healthy controls were included in the study. Cases were further divided into nondiabetic hyperuricaemic and diabetic-hyperuricaemic subgroups. Routine blood biochemistry including high sensitivity C-Reactive Protein (hs-CRP), Plasminogen Activator Inhibitor-1 (PAI-1) and lipid profile was performed to assess endothelial function and hypercoagulability. Data were expressed as Mean±SEM.
Results: Levels of hs-CRP and PAI-1 were significantly higher in diabetic hyperuricaemics (p<0.001) and nondiabetic hyperuricaemics (p<0.001) compared to controls. The difference was not significant between the hyperuricaemic subgroups. Serum Uric Acid (UA) levels showed a significantly positive correlation with hs-CRP (r=0.554, p<0.001) and PAI-1 (r=0.525, p=0.003) levels among the cases. Association between UA and glucose was not significant in diabetic hyperuricaemics (r=0.270, p=0.15).
Conclusion: HU is associated with endothelial dysfunction and prothrombotic state leading to increased cardiovascular risk. Hyperglycaemia does not have a direct causal role in HU associated cardiovascular risk.
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